DOI:
https://doi.org/10.7439/ijpr.v5i6.2095
Abstract
Antioxidants are our first line of defense against free radical damage, and are critical for maintaining optimum health and wellbeing. Catalase (CAT), superoxide dismutase (SOD), and thiobarbituric acid reactive Substances (TBARS) estimated using liver homogenate. Dose dependent antioxidant activity was obtained against DPPH radical. Levels of serum markers AST, ALT, ALP, TB and total protein were significantly increased in CCl4 treated rats. Increase in antioxidant enzymes CAT and SOD and a decrease in the level of TBARS was observed.
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References
Braca A, Tommasi ND, Bari LD, Pizza C, Politi M, Morelli I. Antioxidant principles from Bauhinia terapotensis. Journal of Natural Products 2001; 64:892–895.
Sies H. Oxidative stress, introductory remarks. In: Oxidative Stress.(Sies H, Ed.) Academic Press, London 1985; 1-8.
Toborek M, Wasik T, Drozdz M et al. Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure. Metabolism 1992; 41:1229-1232.
Klahr S. Oxygen radicals and renal diseases. Miner Electrolyte Metab1232; 23:140-143.
Nooman A. KHALAF, Ashok K. SHAKYA, Atif AL-OTHMAN, Zaha EL-AGBAR, Husni FARAH., Turkish Journal of Biology, 32 (2008) 51-55
Langseth, L. From the Editor: Antioxidants and Diseases of the Brain. Antioxidant Vitamins Newsletter 1993; 4:3.
Halliwell, B., Free Radicals, Antioxidants, and Human Disease: Curiosity, Cause, or Consequence? Lancet 1994; 344:721-724.
Devasagayam TPA, Tilak JC, Boloor KK et al. Review: Free radical and antioxidants in human health. Curr Stat Fut Pros JAPI 53: 794-804, 2004.
Nadkarni KM. Indian Materia Medica, 1975; 2: 253.
Ghani A. Medicinal Plants of Bangladesh with Chemical Constituents and Uses. 2nd Edn. Asiatic Society of Bangladesh, Dhaka, Bangladesh 267.
Asolkar LV, Kakkar and Chakre. Second Supplement to Glossary of Indian Medicinal Plants with active principles. Part-1 (A-K), CSIR, New Delhi 1992.
Zulfkar Latief Qadrie, R. Anandan, Beena Jacob, Humaira Ashraf: Liver Protective Activity of Indoneesiella echioides Against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Rats. Pharmacologyonline 2011; 2: 416-429
Kokate CK. Preliminary phytochemical screening, Practical pharmacognosy. New Delhi: Vallabh Prakashan: 107-113, (1994).
Asokkumar K, Umamaheswari M, Sivashanmugam AT, Subhadradevi V, Subhashini N, Ravi TK: Free radical scavenging and antioxidant activities of Glinus oppositifolius (carpet weed) using different in vitro assay systems. Pharm. Biol, 2009; 47(6), 474–82.
Mensor LL, Menezes FS, Leitao GG, Reis AS, dos Santos TC, Coube CS and Leitao SG: Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytother. Res., 2001; 15: 127-130.
Aebi H: Catalase in vitro. Meth. Enzymol, 1984;105, 121–26.
Kakkar P, Das B, Viswanathan PN: A modified spectrophotometric assay of SOD. Indian J. Biochem. Biophys, 1984; 2, 130-32.
Asokkumar K, Umamaheswari M, Bahrudeen A, Sivashanmugam AT, Subhadradevi V, Ravi TK: Antioxidant and hepatoprotective activities of the fractions of Ficus microcarpa sing in vitro and ex vivo assay systems. Functional Plant Science and Biotechnology, 2010; 4(1), 17–27.
Halliwell B, Gutteridge JMC: Free radicals in biology and medicine, 1999; 3rd Ed, Oxford University Press, Oxford.
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