Clinical Improvement In COVID19 Patients With Timely Intervention Of Panchagavya Medicine: A Preliminary Finding



  • Dr. Pavan Tijare

    Panchgavya Ayurved Physician & Consultant (Govigyan Anusandhan Kendra, Deolapar, Nagpur)

  • Dr. Niteen Ambatkar

    Panchgavya Ayurved Physician & Consultant (Govigyan Anusandhan Kendra, Deolapar, Nagpur)

  • Dr. Vaibhav Tiwari

    Guide (Principal Shri Shankarcharya Institute Of Pharmaceutical Sciences, Junwani Bhilai C.G)


COVID-19, Panchgavya, natural compounds, antiviral, Gomutra, Cow urine distillate


Introduction: The World Health Organization declared the COVID-19 outbreak as a pandemic on March 11th, 2020. There is no approved medication suggested by WHO till date. Panchagavya and other traditional medicines have been used from thousands of years for many chronic diseases where no treatment possible by modern medicines.

Methods: Gomutra Arka i.e. Cow urine distillate was given, along with prescribed medication to COVID-19 positive patients.

Result: All three patients recovered from COVID-19 with no complications.

Discussion: Many researches on cow urine and its components (like free volatile fatty acids, phenolic compounds, inorganic and organic compounds) showed that it has not only potent and significant inhibition effects on viral and bacterial replication but also enhances the activity of antiviral and antibacterial drugs. Some scientific literatures also reveal that Cow urine and its components have antioxidant and immunomodulator activities which are also helpful in recovery of COVID-19.

Conclusion: The recovery of these three patients suggests that there is significant role of Panchagavya Medicine i.e. Gomutra Arka (CUD) as a safe and effective therapy of COVID-19. Hence, further research on large population and in vitro study is required to analyze effect Gomutra Arka (CUD) on COVID-19.


Download data is not yet available.


Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W. A pneumonia outbreak associated with a new corona virus of probable bat origin. Nature. 2020;579:270

Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y. Epidemiological and clinical characteristics of 99 cases of 2019 novel corona virus pneumonia in wuhan, China: a descriptive study. Lancet. 2020;395:507

Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395: 497

Stebbing, Justin Phelan, Anne Griffin, IvanTucker, et al COVID-19: combining antiviral and anti-inflammatory treatments. Lancet 2020;4;400-02

Peiris JSM, Chu CM, Cheng VCC, et al. Clinical progression and viral load in a community outbreak or coronavirus-associated SARS pneumonia: a prospective study. Lancet 2003; 361: 1767

World Health Organisation. COVID-19 strategic preparedness and response plan operational planning guidelines to support country preparedness and response. 2020.

National Health Policy. Government of India; 2017. Available at: [Accessed 9 April 2020].

TCM aids treatments of over 60,000 COVID-19 cases in China – xinhua Xinhua. 2020. Available at:

Liang T. Handbook of COVID-19 prevention and treatment. 2020

Shah H. Exploring the effectiveness of traditional Chinese medicine against COVID-19. Pharma R&D Today. Elsevier; 2020. Available at: https://pharma against-covid-19

Salzberger B., Gl

Grasselli G., Pesenti A., Cecconi M. Critical care utilization for the covid-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response. J Am Med Assoc. 2020 doi: 10.1001/jama.2020.4031.

Onder G., Rezza G., Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to covid-19 in Italy. J Am Med Assoc. 2020 doi: 10.1001/jama.2020.4683.

Ren J-l, Zhang A.-H., Wang X.-J. Traditional Chinese medicine for covid-19 treatment. Pharmacol Res. 2020;155:104743. doi: 10.1016/j.phrs.2020.104743.

Cui H.T., Li Y.T., Guo L.Y., Liu X.G., Wang L.S., Jia J.W. Traditional Chinese medicine for treatment of coronavirus disease 2019: a review. Trad Med Res. 2020;5:65

National health commission of the people’s republic of china. Guideline on diagnosis and treatment of covid-19 (trial 6th edition) 2020. http://www.Nhc.Gov.Cn/xcs/zhengcwj/202002/8334a8326dd94d329df351d7da8aefc2.Shtml [in chinese]

Tillu G., Chaturvedi S., Chopra A., Patwardhan B. Public health approach of Ayurveda and Yoga for COVID-19 prophylaxis. J Altern Complement Med. 2020 doi: 10.1089/acm.2020.0129.

Rastogi S. Viral epidemics and traditional health care systems: it

Patwardhan B., Chavan-Gautam P., Gautam M., Tillu G., Chopra A., Gairola S. Ayurveda rasayana in prophylaxis of covid-19. Curr Sci. 2020;118:1158

Jarald, E. Edwin, Edwin, S., Tiwari, V., Garg, R. and Toppo, E.(2008)’Antidiabetic Activity of Cow Urine and a Herbal Preparation Prepared Using Cow Urine’,Pharmaceutical Biology,46:10,789

Jarald E, Edwin S, Tiwari V, Garg R and Toppo E. (2008). Antioxidant and Antimicrobial Activities of cow urine. Global Journal of Pharmacology. 2(2);20-22

Pathak ML, Kumar A. Cow praising and importance of Panchyagavya as medicine. Sachitra Ayurveda 2003?5:569.

Rammanohar P, Sushila Kataria, Unni Krishana P M Prasad M Vasudevan Nampoothir, Pooja Sharma , Manish Kumar Singh Kuldeep Kumar Naresh Trehan. Ayurvedic clinical Profile of COVID19 -A preliminary report. Journal of Ayurveda and integrative medicine;2020; article in press.

D D Gosavi, D Sachdev, K Salwe. Immunomodulatory and Antioxidant Effect Of Gomutra Ark in Rats J MGIMS, September 2011, Vol 16, No (ii), 37-41

Chauhan RS, Singh BP, Singhal LK. Immunomodulation with Kamdhenu ark in mice. J Immunol Immunopathol. 2001;3:74

Shelly Sharma , Pooja Chadha and , Madhu Sharma. Kamdhenu Ark

Aanuradha Verma, Babita Kumar, Manish K. Singh and M.D. Kharya Immunomodulatory Potential Of Cow Urine Der Pharmacia Lettre, 2011, 3(2): 507-513.

Dutta D, Devi SS, Krishnamurthi K, Chakrabarti T. Anticlastogenic effect of redistilled cow’s urine distillate in human peripheral lymphocytes challenged with manganese dioxide and hexavalent chromium. Biomed Environ Sci. 2006;19:487

Yonezawa T., Kurata R., Yoshida K., MurayamaM.A., Cui X. and Hasegawa A. Free Fatty Acids- Sensing G Protein

Hirasawa A, Hara T., Ichimura A and Tsujimoto G. Free Faaty acid receptors and their physiological role in metabolic regulation. Yakugaku Zasshi. 2011;131(12):1683-9 ( article in Japanese)

Rana R, De S. In vitro antimicrobial screening of cow urine

Minocheherhomji FP, Vyas BM. Study of the antimicrobial activity of cow urine and medicinal plant extracts on pathogenic human microbial strains. Int J Adv Pharm Biol Chem. 2014;3:836

Kekuda PT, Nishanth BC, Kumar PS, Kamal D, Sandeep M, Megharaj HK. Cow urine concentration: A potent agent with antimicrobial and anthelmintic activity. J Pharm Res. 2010;3:1025

Sarsar V, Selwal KK, Selwal MK, Pannu R, Tyagi PK. Evaluation of antibacterial activity of photoactivated cow urine against human pathogenic strains. Environ Exp Biol. 2013;11:201

Tyagi PK, Tyagi S, Sarsar V, Pannu R. Cow urine: An antimicrobial activity against pathogens and their possible uses. Int J Pharm Res Sch. 2013;2:427

Shah CP, Patel DM, Dhami PD, Kakadia J, Bhavsar D, Vachhani UD, et al. In vitro screening of antibacterial activity of cow urine against pathogenic human bacterial strains. Int J Curr Pharm Res. 2011;3:91

Sathasivam A, Muthuselvam M, Rajendran R. Antimicrobial activities of cow urine distillate against some clinical pathogens. Glob J Pharmacol. 2010;4:41

Vats S, Kumar R, Negi S. Natural food that meet antibiotics resistance challenge: In vitro synergistic antimicrobial activity of Azadirachta indica, Terminalia chebula, Piper nigrum and photoactivated cow urine. Asian J Pharm Biol Res. 2012;2:122

Yadav H, Yadav M, Jain S, Bhardwaj A, Singh V, Parkash O, et al. Antimicrobial property of a herbal preparation containing Dalbergia sissoo and Datura tramonium with cow urine against pathogenic bacteria. Int J Immunopathol Pharmacol. 2008;21:1013

Deshmukh SS, Rajgure SS, Ingole SP. Antifungal activity of cow urine. IOSR J Pharm. 2012;2(5):27

Vijayalakshmi R, Saranya VT. Effect of

Dhama K, Chauhan RS, Singhal L. Anti-cancer activity of cow urine: Current status and future directions. Int J Cow Sci. 2005;1:1

European patent no EP1330253: Use of bioactive fraction from cow urine distillate (‘go mutra’) as a bio-enhancer of anti-infective, anti-cancer agents and nutrients

Jain NK, Gupta VB, Garg R, Silawat N. Efficacy of cow urine therapy on various cancer patients in Mandsaur district, India: A survey. Int J Green Pharm. 2010;4:29

Khanuja SP, Kumar S, Shasany AK, Arya JS, Darokar MP. Use of bioactive fraction from cow urine distillate (

Kumar A, Kumar P, Singh LK, Agrawal DK. Pathogenic effects of free radicals and their prevention through cowpathy. Indian Cow. 2004;6:27

Maheshwari AK, Gupta AK, Das AK. Effect of cow urine on wounds. Indian Cow. 2004;1:19

Mishra R, Das LL, Sharma AK, Singh KK. Histomorphological evaluation of wound healing potential of cow urine in goats. Indian J Vet Pathol. 2009;33:197

US 6,410,059 : Pharmaceutical composition containing cow urine distillate and an antibiotic

Singh S. Cow urine has anti-leishmania donovani effect in vitro. Int J Cow Sci. 2005;1(2):72

Kekuda PT, Nishanth BC, Kumar PS, Kamal D, Sandeep M, Megharaj HK. Cow urine concentration: A potent agent with antimicrobial and anthelmintic activity. J Pharm Res. 2010; 3:1025




How to Cite

Tijare P, Ambatkar N, Tiwari V. . Int J of Pharmc Res [Internet]. 2020 Jun. 28 [cited 2022 Nov. 15];10(6):e5449. Available from:



Research Articles

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

Leave a Comment