Hypolipidemic effect of ethanolic extract from Pandanus amaryllifolius leaves on triton WR-1339-induced hyperlipidemia in mice



  • Ngoc Trinh Huynh


  • Duong Ngoc Thoi Nguyen

  • Manh Hung Tran


Hyperlipidemia, Triton WR – 1339, Pandanus amaryllifolius, HMG – CoA reductase


The 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase is the key enzyme of cholesterol biosynthesis pathway in the liver. The present work aimed at investigating the hypolipidemic effect of total extract from Pandanus amaryllifolius Roxb. (PA) leaves through the inhibition of HMG-CoA reductase activity. PA extract showed a moderate in vitro inhibitory effect on activity of HMG-CoA reductase with IC50 value at range of 126.42 microg/ml as compared to that of atorvastatin about 7.77 ng/ml. In a mouse model of hyperlipidemia induced by a single intravenous injection of triton WR-1339, oral administration of PA extract significantly reduced total cholesterol as well as triglyceride levels as compared to hyperlipidemic mice. Furthermore, PA extract also inhibited HMG-CoA reductase activity with reduction of 32%, which were comparable to those of positive control, atorvastatin. In conclusion, PA extract clearly showed promising hypolipidemic effect by inhibiting HMG-CoA reductase activity.


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How to Cite

Huynh NT, Nguyen DNT, Tran MH. . Int J of Pharmc Res [Internet]. 2018Dec.31 [cited 2020Jun.1];8(12):131-6. Available from: https://ssjournals.net/index.php/ijpr/article/view/4983


Vol. 8 No. 12 (2018): Dec


Research Articles

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

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