Novel therapeutic strategies for treatment of liver cancer


Methodology

Authors


  • Vimalavathini R.


    Department of Pharmacology,
    College of Pharmacy, MTPG & RIHS,
    Pondicherry – 605006

  • Marthiyana Begum M


    Department of Pharmacology,
    College of Pharmacy, MTPG & RIHS,
    Pondicherry – 605006

  • Suganthi A


    Department of Pharmacology,
    College of Pharmacy, MTPG & RIHS,
    Pondicherry – 605006

  • Vimalrai T


    Department of Pharmacology,
    College of Pharmacy, MTPG & RIHS,
    Pondicherry – 605006

  • Kavimani S.


    Department of Pharmacology,
    College of Pharmacy, MTPG & RIHS,
    Pondicherry – 605006

DOI:

https://doi.org/10.7439/ijpr.v7i5.4147

Abstract

Liver cancer is the most common type of solid tumor with poor prognosis. Various environmental, genetic and epigenetic factors including aberrant molecular signaling pathways play a significant role in pathogenesis of liver cancer. Targeting these molecular pathways has paved the way for evolution of molecular targeted drugs. Liver being less immunogenic strategies to improve immunosurveillance evasion by cancer cells has been addressed using immunotherapy. Research on novel therapeutic strategies such as immunotherapy, molecular targeted therapy, gene therapy is ongoing. This review aims to discuss current trends and recent developments in the field of liver cancer therapy.

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Author Biography

Vimalavathini R., Department of Pharmacology,
College of Pharmacy, MTPG & RIHS,
Pondicherry – 605006

Assistant professor

Department of Pharmacology

College of Pharmacy

MTPG & RIHS

Pondicherry – 605006

References

Pascual S, Herrea I, Irurzun J. New advances in hepatocellular carcinoma. World J Hepatol 2016; 8(9): 421-38.

Terry K, Copur MS. Molecular targeted therapy of hepatocellular carcinoma. Journal of Cancer Therapy, 2013;4:426-39.

Tsuchiya N, Sawada Y, Endo I, Uemura Y, Nakatsura T. Potentiality of immunotherapy against hepatocellular carcinoma. World J Gastroenteral 2015; 21(36): 10314-26.

Li S, Yang F, Ren X. Immunotherapy for hepatocellular carcinoma. Drug Discoveries and Therapeutics.2015; 9(5):363-71.

Avila MA, Berasain C, Sangro B, Prieto J. New therapies for hepatocellular carcinoma. Oncogene. 2006 ;25(27):3866-84.

Llovet JM, Bruix JD. Molecular targeted therapies in hepatocellular carcinoma. Hepatology. 2008;48(4):1312–27.

Connock M, Round J, Bayliss S, Tubeuf S, Greenheld W, Moore D. Sorafenib for the treatment of advanced hepatocellular carcinoma. Health Technol Assess. 2010;14 Suppl 1:17-21.

Shin JW, Chung Y. Molecular targeted therapy for hepatocellular carcinoma: Current and future. World J Gastroenterol, 2013; 19(37): 6144-55.

Wang C, Wey K, Mo L, Chang K, Lin R, Kuo J. Current trends and recent advances in diagnosis, therapy and prevention of hepatocellular carcinoma. Asian Pac J Cancer Prev. 2015;16(9):3595-604.

Schlachterman A, Craft WW, Hilgenfeldt E, Mitra A, Cabrera R. Current and future treatments for hepatocellular carcinoma. World J Gastroenterol 2015;21(28): 8478-91.

Gong XL, Qin S. Progress in systemic therapy of advanced hepatocellular carcinoma. World J Gastroenterol. 2016;22(29):6582–94.

Chen C, Wang G. Mechanism of HCC and challenges and opportunities for molecular targeted therapy. World J Hepatol.2015; 7(15): 1964-70.

Greten TF, Manns MP, Korangy F. Immunotherapy of hepatocellular carcinoma, J Hepatol. 2006;45(6):868-78.

Aravalli R, Steer CJ. Immune-Mediated Therapies for Liver Cancer. Genes (Basel). 2017;8(2). doi: 10.3390/genes8020076.

Willimsky G, Protzer U, Knolle P, Heikenwalder M. Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key? Oncotarget 2013;4(8):1117-8.

Sangiolo D. Cytokine induced killer cells as promising immunotherapy for solid tumors. Journal of Cancer 2011, 2:363-8.

Kudo M. Immune checkpoint inhibition in hepatocellular carcinoma: Basics and ongoing clinical trials. Oncology 2017;92(suppl 1):50–62.

Hernández-Alcoceba R, Sangro B, Prieto J. Gene therapy of liver cancer. World J Gastroenterol. 2006;12(38):6085–97.

Published

2017-06-01

How to Cite

1.
R. V, M MB, A S, T V, S. K. . Int J of Pharmc Res [Internet]. 2017Jun.1 [cited 2020May31];7(5):99-102. Available from: https://ssjournals.net/index.php/ijpr/article/view/4147

Issue

Vol. 7 No. 5 (2017): May

Section

Review Article

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

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