New simplex Type 1 lytic infection pyridine system derivative as a novel goal against Herpes



  • Marcelo do Nascimento Costa

  • Viveca Giongo

  • Claudio Cesar Cirne-Santos

  • Caroline de Souza Barros

  • Valria Garrido

  • Thiago Moreno Lopes e Souza

  • Juliana Abrantes

  • Luiz Carlos da Silva Pinheiro

  • Srgio Pinheiro

  • Alice Maria Rolim Bernardino

  • Izabel Palmer Paixão

    Universidade Federal Fluminense



The pyridine system derivatives have been studied as antiviral drug new models against HIV infection using bioisosterism as a powerful tool. In the last decades, the number of this work, thienopyridine derivatives were evaluated as an HSV-1 inhibitor to since the elevated number of acyclovir resistance in immunocompromised patients could promote a continuous viral pool increase and disease recurrence. In these substances, thienopyridine derivative with radical nitrate in para position (109) was able to inhibit 99% of HSV-1 replication in Vero cells with EC 50 value of 100 pM, and SI value three times higher than acyclovir. In kinetic enzymatic assay this substance was also able to inhibit about 50% of HSV-1 DNA polymerase but in a non-competitive mechanism a new synergic system to control herpes infections. Preliminary in vivo model studies revealed that substance 109 is toxic when administered in 300 g/mL concentrations. In this work, we concluded that thienopyridine derivatives can be considered a promising new anti-HSV-1 drug and can be used for clinical testing.


Download data is not yet available.

Author Biography

Izabel Palmer Paixão, Universidade Federal Fluminense

Departamento de Biologia Celular e Molecular



How to Cite

Nascimento Costa M do, Giongo V, Cirne-Santos CC, Souza Barros C de, Garrido V, Lopes e Souza TM, Abrantes J, Silva Pinheiro LC da, Pinheiro S, Rolim Bernardino AM, Paixão IP. . Int J of Pharmc Res [Internet]. 2017Jul.28 [cited 2020Jul.3];7(7):148-53. Available from:


Vol. 7 No. 7 (2017): Jul


Research Articles

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

Leave a Comment