A comparative study of antinociceptive effects of Tapentadol, amitriptyline and combination of both in albino rats

Authors

Rita Kumari

Rajendra Institute of Medical Sciences (RIMS), Ranchi
Arijit Das

Junior Resident,
Department of Pharmacology,
Rajendra Institute of Medical Sciences (RIMS), Ranchi
Abha Kumari

Assistant Professor,
Department of Pharmacology,
Rajendra Institute of Medical Sciences (RIMS), Ranchi
Satish Chandra

Professor, Department of Pharmacology, Rajendra Institute of Medical Sciences (RIMS), Ranchi
Manju Gari

Professor and Head,
Department of Pharmacology,
Rajendra Institute of Medical Sciences (RIMS), Ranchi

DOI:

https://doi.org/10.7439/ijpr.v6i12.3775

Abstract

Objective: The aim of the study was to investigate the possible antinociceptive effects of combination of Tapentadol and Amitriptyline in comparison to the single drugs. Materials and Methods: After approval from Animal Ethics Committee, a total of twenty four (n = 24) healthy male albino rats were divided into four groups of six rats in each. Group Iwas control,Gr. II tapentadol treated,Gr. III amitriptyline treated and Gr. IV treated with both tapentadol and amitriptyline. The test drugs administered thirty minutes prior to the procedure once at weekly intervals (on day 0, 7, 14, 21 and 28) for up to 28 days. Haffners tail clip and formalin test were conducted to evaluate the antinociceptive effects. Results: In both animal test models the antinociceptive effects observed from the combination of tapentadol and amitriptyline was greater than that produced by tapentadol and amitriptyline alone. Conclusion: From the results obtained in this study, we can conclude that coadministration of tapentadol and amitriptyline showed much greater antinociceptive effects than either drug singly . Thus, in combined form they can potentiate each others action via multifactorial mechanism.

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Author Biography

Rita Kumari, Rajendra Institute of Medical Sciences (RIMS), Ranchi

Junior Resident, Department of Pharmacology,

Published

2016-12-30

How to Cite

Kumari R, Das A, Kumari A, Chandra S, Gari M. . Int J of Pharmc Res [Internet]. 2016Dec.30 [cited 2020May31];6(12):364-8. Available from: https://ssjournals.net/index.php/ijpr/article/view/3775

Issue

Vol. 6 No. 12 (2016): Dec

Section

Research Articles

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