DOI:
https://doi.org/10.7439/ijpr.v6i10.3701
Keywords:
Anti-inflammatory, Anti-oxidant, Neuroprotection, Parkinson animal model, Thuja orientalis
Abstract
Introduction: Neuro-inflammation, increased microglial activation & interaction and oxidative stress are the new targets for Parkinson management. Protective effect of NSAIDs and anti-oxidants has been demonstrated in many animal studies with inconclusive epidemiological reports. Thuja orientalis (TOFE) a common shrub found widely in India has shown neuro-protective effect against 6-OHDA induced toxicity on SH-SY cells. Aim & Objective: To assess and compare neuro-protective effect of TOFE with Ibuprofen and vitamin E in haloperidol induced rat models of Parkinson.
Methodology: 6 adult male Sprague Dawley rats each in 4 groups were given Thuja orientalis (500mg/kg) / Ibuprofen (100mg/kg) and Vitamin E (35mg/kg) orally followed 1 hour latter by haloperidol. (2mg/kg.IP) for 7 days. Motor activity and rigidity were assessed with actophotometer and common bar test. Catatonia scoring was also done. One way ANOVA and Kruscal-Wallis tests followed by Dunns multiple comparison test were used for statistical significance of <0.05.
Results: Significant reduction in motor activity was observed in all on 7th day. Mild protection by thuja orientalis against motor rigidity was noted with p-value of 0.032 and against catatonia with 2.5 scoring.
Conclusion: Neuroprotective effect shown in-vitro experiments by anti-oxidants and anti-inflammatory drugs did not show any significant effects in our in vivo animals study against clinical features as seen in Parkinsons disease. This inconclusive neuroprotective effect of standards & thuja observed signifies that all preclinical data from in vitro studies cannot be effectively extrapolated to in vivo animal & human studies due to many variations. Further probe in this aspect is suggested.
Downloads
- PDF
Copyright (c) 2016 International Journal of Pharmacological Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
-
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- Author must Submit Copyright form After acceptance of Article
