DOI:
https://doi.org/10.7439/ijpr.v6i7.3329
Abstract
The objective of the present study is to evaluate the hypoglycemic and antihyperglycemic effect of aqueous-methanolic extract of Olax acuminata and Bauhinia accuminata leaves in normoglycemic and alloxan induced diabetic mice. For hypoglycemic study, normoglycemic mice were administered with varying doses of extracts and the optimal dose was selected for glucose tolerance test (GTT). For antihyperglycemic study, the optimal dose of extract was administered to diabetic mice and GTT was also performed. In addition, elements in the leaves of plants were also analyzed to relate the presence of elements to their anti-diabetic property. At the dose of 250 mg/kg b.w., O. acuminata leaves extract showed significant reduction in the blood glucose level in normoglycemic and diabetic mice while B. acuminata leaves extract showed significant reduction at 500 mg/kg b.w. Glucose tolerance was also improved in both normal and diabetic mice on administration of the extracts. The results were compared with those of insulin and metformin which were used as standard drugs. Elements found in the leaves of O. acuminata were Cu, Cr, Mn, Zn, Fe, V, Mg, K, C, Sr and P whereas B. acuminata leaves contain all the above elements except for V and Pb. These mention elements are widely known for regulating blood glucose level. The aqueous-methanolic leaves extract of both the plants demonstrates hypoglycemic and antihyperglycemic effect, thus, could be promising plants in the treatment of diabetes.
Downloads
- PDF
Published
How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
-
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- Author must Submit Copyright form After acceptance of Article