Hepatoprotective and Antioxidant potential of Tephrosia Purprea in Paracetamol Induced Hepatotoxicity


Methodology

Authors


  • Shivshankar M. Gunjegaonkar


    Department of Pharmacology,
    JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune.

  • Sandip S Kshirsagar


    Department of Pharmaceutical Chemistry,
    JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune

  • Jayendrasingh P. Bayas


    Department of Pharmceutics,
    JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune

DOI:

https://doi.org/10.7439/ijpr.v6i3.3061

Keywords:


Propionibacterium acnes, Pus, Anaerobic microorganism, Skin disease, Pimples

Abstract

The present study was designed to evaluate Hepatoprotective and antioxidant potential of Tephrosia Purprea whole plant aqueous extract in paracetamol intoxicated rats. 75mg/kg and 150mg/kg of aqueous extract were administered orally once a daily for seven days. Animals were challenged with paracetamol on 5th day of treatment protocol. Elevated serum levels of transaminases, alkaline phosphatase and bilirubin (direct and total) were restored significantly by the extract. Silymarine (reference standard) exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity. The biochemical parameters were supplemented with histopathological studies. In-vitro free radical scavenging activity was screened and results concluded that possible mechanism of hepatoprotective activity may be due to its free radical scavenging activity.

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References

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Published

2016-03-30

How to Cite

1.
Gunjegaonkar SM, Kshirsagar SS, Bayas JP. . Int J of Pharmc Res [Internet]. 2016Mar.30 [cited 2020Jul.5];6(3):104-8. Available from: https://ssjournals.net/index.php/ijpr/article/view/3061

Issue

Vol. 6 No. 3 (2016): Mar

Section

Research Articles

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

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