Hepatoprotective and Antioxidant potential of Tephrosia Purprea in Paracetamol Induced Hepatotoxicity



  • Shivshankar M. Gunjegaonkar

    Department of Pharmacology,
    JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune.

  • Sandip S Kshirsagar

    Department of Pharmaceutical Chemistry,
    JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune

  • Jayendrasingh P. Bayas

    Department of Pharmceutics,
    JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune




Propionibacterium acnes, Pus, Anaerobic microorganism, Skin disease, Pimples


The present study was designed to evaluate Hepatoprotective and antioxidant potential of Tephrosia Purprea whole plant aqueous extract in paracetamol intoxicated rats. 75mg/kg and 150mg/kg of aqueous extract were administered orally once a daily for seven days. Animals were challenged with paracetamol on 5th day of treatment protocol. Elevated serum levels of transaminases, alkaline phosphatase and bilirubin (direct and total) were restored significantly by the extract. Silymarine (reference standard) exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity. The biochemical parameters were supplemented with histopathological studies. In-vitro free radical scavenging activity was screened and results concluded that possible mechanism of hepatoprotective activity may be due to its free radical scavenging activity.


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How to Cite

Gunjegaonkar SM, Kshirsagar SS, Bayas JP. . Int J of Pharmc Res [Internet]. 2016Mar.30 [cited 2020Jul.5];6(3):104-8. Available from: https://ssjournals.net/index.php/ijpr/article/view/3061


Vol. 6 No. 3 (2016): Mar


Research Articles

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