Hepatoprotective and Antioxidant potential of Tephrosia Purprea in Paracetamol Induced Hepatotoxicity

Authors

Shivshankar M. Gunjegaonkar

Department of Pharmacology,
JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune.
Sandip S Kshirsagar

Department of Pharmaceutical Chemistry,
JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune
Jayendrasingh P. Bayas

Department of Pharmceutics,
JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune

DOI:

https://doi.org/10.7439/ijpr.v6i3.3061

Keywords:

Propionibacterium acnes, Pus, Anaerobic microorganism, Skin disease, Pimples

Abstract

The present study was designed to evaluate Hepatoprotective and antioxidant potential of Tephrosia Purprea whole plant aqueous extract in paracetamol intoxicated rats. 75mg/kg and 150mg/kg of aqueous extract were administered orally once a daily for seven days. Animals were challenged with paracetamol on 5^th day of treatment protocol. Elevated serum levels of transaminases, alkaline phosphatase and bilirubin (direct and total) were restored significantly by the extract. Silymarine (reference standard) exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity. The biochemical parameters were supplemented with histopathological studies. In-vitro free radical scavenging activity was screened and results concluded that possible mechanism of hepatoprotective activity may be due to its free radical scavenging activity.

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Published

2016-03-30

How to Cite

Gunjegaonkar SM, Kshirsagar SS, Bayas JP. . Int J of Pharmc Res [Internet]. 2016Mar.30 [cited 2020Jul.5];6(3):104-8. Available from: https://ssjournals.net/index.php/ijpr/article/view/3061

Issue

Vol. 6 No. 3 (2016): Mar

Section

Research Articles

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