Screening of cardioprotective activity of leaves of Andrographis paniculata against isoproterenol induced myocardial infarction in rats



  • Dipendra Kumar Sah

    Department of Pharmacology,
    Karnataka College of Pharmacy,
    Thirumenahalli Bangalore-560064,

  • Nagarathana P.K.M.

    Department of Pharmacology,
    Karnataka College of Pharmacy,
    Thirumenahalli Bangalore-560064,



Objective: The objective of the present study was to investigate the cardioprotective effects of methanolic extract of leaves of Andrographis paniculata against Isoproterenol-induced myocardial infarction (MI) in rats. Method: The rats were divided into five experimental groups viz., Normal control, ISO-treated (Disease control), Propranolol (10 mg/kg + ISO), Andrographis paniculata (100 mg/kg +ISO) and Andrographis paniculata (200 mg/kg + ISO). Myocardial infarction in rats was induced by the administration of isoproterenol at a dose of 85mg/kg i.p., the rats in group IV and group V were pretreated with methanolic extract of Andrographis paniculata in the dose of 100mg/kg b.w. and 200mg/kg b.w. through oral route. Cardiac marker enzymes, lipid profile and antioxidant enzymes as biomarker of cardiotoxicity were determined in experimental animals. Result: Animals treated with flavonoid of leaves of Andrographis paniculata showed significant decrease in LDL-Cholesterol, total cholesterol, Triglycerides, AST, ALT, ALP, antioxidant enzymes viz., superoxide dismutase, catalase LPO and increase in HDL-Cholesterol and further was confirmed by histopathological study. Conclusion: The results of the study demonstrate that Andrographis paniculata strongly protected the myocardium against isoproterenol-induced infarction and suggest that the cardioprotective effects could be related to antioxidant activities.


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How to Cite

Sah DK, P.K.M. N. . Int J of Pharmc Res [Internet]. 2016 Jan. 30 [cited 2022 Jun. 20];6(1):23-8. Available from:



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