Diclofenac Induced Fixed Drug Eruption


Methodology

Authors


  • Umeshchandra C Honnaddi


    PG Resident in MD Pharmacolgy,
    Department of Pharmacology, M.R. Medical College, Sedam Road Gulbarga

  • Banderao V. Patil


    Department of Pharmacology,
    GIMS, Sedam Road Gulbarga, Karnataka,

  • Madhushalini U. Honnaddi


    Vydehi Institute of Medical Sciences & Research Centre (VIMS), Bangalore, Karnataka,

  • Tharangini S. R


    Department of Pharmacology,
    M.R. Medical College, Sedam Road Gulbarga,

  • Dr. Sajid


    Department of Pharmacology,
    M.R. Medical College, Sedam Road Gulbarga,

DOI:

https://doi.org/10.7439/ijpr.v6i2.2883

Keywords:


Momordica charantia Linn., Diabetes mellitus, Terpenoids, Charantin

Abstract

Background: Diclofenac is the most commonly used non-steroidal anti-inflammatory drug (NSAID) for treating various inflammatory and painful conditions. It is generally well tolerated; gastric upset is the most common adverse effect. However very few cases of fixed drug eruptions were reported. Here we present a case of . A 62 year old male patient developed fixed drug eruptions with plaques on left thigh two days after receiving diclofenac for osteoarthritic pain. Other etiologies including insect bite, infections were ruled out. One week later after stopping the drug, the lesions were subsided. Diclofenac was strongly suspected as the casual drug. CD8+ effector T-cells have shown to play an important role. However it seems to be a reversible and drug related event. Although it is not life-threatening, fixed drug eruption can have significant effect on the quality of life of patients. Conclusion: Diclofenac is one of the most commonly prescribed NSAIDs by the Physicians. It is usually well tolerated, gastric upset is the most common adverse effect noted with this drug. This case is being reported to highlight a drug as safe as Diclofenac may also be associated with Fixed Drug Eruptions.

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Author Biography

Umeshchandra C Honnaddi, PG Resident in MD Pharmacolgy,
Department of Pharmacology, M.R. Medical College, Sedam Road Gulbarga

Department of Pharmacology

References

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Published

2016-02-28

How to Cite

1.
Honnaddi UC, Patil BV, Honnaddi MU, S. R T, Sajid D. . Int J of Pharmc Res [Internet]. 2016Feb.28 [cited 2020Jul.3];6(2):86-8. Available from: https://ssjournals.net/index.php/ijpr/article/view/2883

Issue

Vol. 6 No. 2 (2016): Feb

Section

Case Report

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