Preclinical Safety Evaluation Of Aqueous Bark Extract Of Saraca Asoca Roxb : Acute And Subacute Oral Toxicity



  • Nutan Balkrishna Chaudhari

    Department of Pharmacology,
    Padm, Dr. D. Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune-411 018, Maharashtra

  • Anupama Suralkar

    Department of Pharmacology,
    Padm, Dr. D. Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune-411 018, Maharashtra

  • Ziyaurrahman AR

    MCE Society’s Allana College of Pharmacy,
    Azam Campus, Camp, Pune



The present study was aimed to investigate the potential toxicity of the aqueous extract of the stem bark of Saraca asoca (SA) in Wistar rats following the OECD guidelines. In acute oral toxicity, female rats received a single dose of 2000 mg/kg of SA and were observed for 14 days. In sub-acute toxicity, doses of 250, 500, 1000 mg/kg/day of SA were administered to rats (males and females) for 28 days. No mortality rate was found in acute toxicity testing but some behavioural changes were recorded in animals. In sub-acute oral toxicity no significant changes in body weight, body temperature, food and water consumption and urine parameters were observed. However, significant alterations in haematological and serum biochemical parameters were noticed in animals receiving higher doses. A significant variation in relative organ weight of liver, spleen and kidney was observed in all test groups of 28 day and 90 day repeated dose oral toxicity testing. Such variation was dose dependent and hence, the present toxicity study indicates that orally administered aqueous bark extract of Saraca asoca may have some toxic effects.


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Author Biography

Nutan Balkrishna Chaudhari, Department of Pharmacology,
Padm, Dr. D. Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune-411 018, Maharashtra

Department of Pharmacology


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How to Cite

Chaudhari NB, Suralkar A, AR Z. . Int J of Pharmc Res [Internet]. 2015Dec.30 [cited 2020May30];5(12):332-7. Available from:


Vol. 5 No. 12 (2015): Dec


Research Articles

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