Effect of L- type Calcium Channel Blocker Nimodipine and T-type Calcium Channel Blocker Flunarizine on Motor Control in Mice


Methodology

Authors


  • Swapnil Balkrishna Kaikade


    Department of Pharmacology,
    ACPM Medical college

  • Nitin D. Pise


    Department of Pharmacology,
    ACPM Medical college

DOI:

https://doi.org/10.7439/ijpr.v5i5.2007

Abstract

Objective: To study the effect of L-type of Calcium channel blocker nimodipine and T-type of calcium channel blocker funarizine on locomotor activity in mice without pretreatment by any other drug.
Materials and method: The study was carried out following permission from the Institutional animal ethics committee. Healthy Swiss albino mice of either sex were selected by the strict inclusion and exclusion criteria and the grouping is done. Group A is control treated with normal saline, Group B and C received two titrated doses of nimodipine while Group D and E received two titrated doses of flunarizine. The animals were then observed for motor control on inclined plane and the Statistical analysis was done by using unpairedt test.
Results: L-type calcium channel blocker nimodipine has dose dependent effect on motor control on inclined plane while the T- type calcium channel blocker flunarizine has no effect on motor control.
Conclusion: Nimodipine has significant dose dependent depressant action on motor control on inclined plane while flunarizine has no effect on the above mentioned parameter.

Downloads

Download data is not yet available.

References

Fleckenstein A. Calcium Channel Blockers. Exper Facts and Therap Prospect. 1983.

Bretzel RG. Prevention and slowing down the progression of the diabetic nephropathy through antihypertensive therapy. J Diabetes Complications. 1997;11: 112-122.

Tsien RW, Lipscombe D, Madison DV, Bley KR, Fax AP. Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci 1988;11: 431-438.

Takahashi E, Niimi K. Modulators of voltage-dependent calcium channels for the treatment of nervous system diseases. Recent Pat CNS Drug Discov. 2009 Jun; 4(2): 96-111.

Mccleskey EW, Fox AP, Feldman DH, Cruz IJ, Olivera BM, Tsien RW, Yoshikami D. Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proc. Natl. Acad. Sci.1987; 84: 4327-4331.

Geer JJ, Dooley DJ, Adams ME. K+-stimulated45Ca2+ flux into rat neocortical mini-slices is blocked by omega-Aga-IVA and the dual Na+/Ca2+ channel blockers lidoflazine and Flunarizine. Neurosci. Lett. 1993;158: 97-100.

Jack A. Grebb. Nifedipine and flunarizine block amphetamine-induced behavioral stimulation in mice. Life Sciences. 1986June;38(26): 2375-2381.

Published

2015-05-30

How to Cite

1.
Kaikade SB, Pise ND. . Int J of Pharmc Res [Internet]. 2015May30 [cited 2020Jul.3];5(5):122-4. Available from: https://ssjournals.net/index.php/ijpr/article/view/2007

Issue

Vol. 5 No. 5 (2015): May

Section

Research Articles

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

Leave a Comment