Prescription pattern of antimicrobials in tertiary care hospital in central India

Objective: Antimicrobial agents are the greatest contribution to 20^th century, which are used for cure and prevention of infections. Widespread use of antimicrobials has facilitated the development of resistance.

Aim: the study was to assess the use of antimicrobials in tertiary care hospital in Maharashtra.

Method: Prescription audit was done to assess the use of antimicrobials. Total 1942 prescriptions were analyzed for average number of drugs prescribed, antimicrobials prescribed by generic name or brand name, percentage of antibiotics among the prescribed drugs, use of fixed drug combinations, if any.

Statistical analysis used: Data was analyzed by percentage.

Result: Demographic analysis showed that out of 1942 patients in OPD, most were male (56.38) and in the age group between 35 to 50 years. In 1942 prescription, 30.25% drugs were antimicrobials. Three drugs were prescribed in 52.15% of the prescription, followed by 4 drugs in 19.78% prescriptions. 79.18% prescriptions were prescribed by generic name while 20.82% were prescribed by brand name. 29.18% of drugs were fixed dose combinations of all the antibiotics were prescribed empirically on the basis of provisional diagnosis. Of the total of antibiotics prescribed, amoxicillin was prescribed in 50.66% of patients, followed by cotrimoxazole in 26.05 % patients, cephalexin (8.50%) were used commonly.

Conclusion: The rational use of antimicrobial agents is one of the main contributors to control worldwide emergence of antibacterial resistance, side effects and reduced cost of the treatment.

Antimicrobials. Prescription, ATC classification

KD TRIPATHI. Antimicrobial drugs, Essentials of Medical Pharmacology.7 th Edition,12. New Delhi JAYPEE Brothers medical publishers, 2013; 688-704

Woldu MA, Suleman S, Workneh N, Berhane H. Retrospective study of the pattern of antibiotic use in Hawassa University Referral Hospital Pediatric Ward, Southern Ethiopia ;J App Pharm Sci; 2013;3(02):93-8.

World Health Organization Financing of Health in India Available from: http://www.ino.searo.who.int/Linkfiles/ Other_Content_WHD11-Seinar _Presentation-WRpdf.

Amane H, Kop P. Prescription analysis to evaluate rational use of antimicrobials. Int J Phar. ma and Biosci 2011; 2(2); 314-319.

Ernest J.S. Resistance to antimicrobials in humans and animals. BMJ ;2005,331:1219-20.

Goossens H. Antibiotic consumption and link to resistance. Clin Microbiol Infect. 2009 Apr;15 Suppl 3:12-15.

MacDougall C, Polk RE. Antimicrobial stewardship programs in health care systems. Clin Microbiol Rev ;2005 Oct;18(4):638-56.

Sharma M, Eriksson B, Marrone G, Dhaneria S, Lundborg CS. Antibiotic prescribing in two private sector hospitals; one teaching and one non-teaching: a cross-sectional study in Ujjain, India. BMC Infect Dis. 2012;12:155.

Khan FA, Singh VK, Sharma S, Singh P. Prospective Study on the Antimicrobial Usage in the Medicine Department of a Tertiary Care Teaching Hospital. Journal of Clinical and Diagnostic Research;2013 Jul ;Vol-7(7):1343-46.

Das BP, Sethi A, Rauniar GP, Sharma SK. Antimicrobial utilization pattern in outpatient services of ENT department of tertiary care hospital of Eastern Nepal. Kathmandu Univ Med J. (KUMJ) 2005;3:370-75.

Sharma R, Khajuria B. Prescribing practices of doctors in rural and urban India. J Clin Diag Res 2009;3;1480?82.

Babalola CP, Awoleye SA, Akinyemi JO, Kotila O. Evaluation of prescription pattern in Osun State (Southwest) Nigeria. J Public Health Epidem 2011;3:94?8.

] Saurabh MK, Jaykaran,Yadav AK, Jyoti N. Study of prescribing pattern and assessment of rational use of drugs in tertiary hospital, Rajasthan. J Pharm Res 2010;3(3):474?7.

Patel V, Vaidya R, Naik D, Borker P. Irrational drug use in India: A prescription survey from Goa. J Postgrad Med. 2005;51:9?12.

Patil S, Kachare A, Shaikh T, Nikam SS. Evaluation and prescribing pattern study of antibacterial agents in Medicine out-patient department of a teaching and referral Hospital in satara district area. UJP 2014;03 (01):75-8.

Hanssens Y, Ismaeili BB. Antibiotic prescription pattern in a medical intensive care unit in Qatar. Saudi Med J 2005;26:1269-76.