Steven johnsons syndrome and toxic epidermal necrolysis: A review



  • Sri ram Anne

    Hindu College of Pharmacy,
    Amaravathi Road, Guntur-522006,

  • Sreya Kosanam

    Hindu College of Pharmacy,
    Amaravathi Road, Guntur-522006,

  • Lakshmi Prasanthi N

    Hindu College of Pharmacy,
    Amaravathi Road, Guntur-522006,



Fallopian Tube, Cancer, Abdominal Pain


Toxic epidermal necrolysis (TEN) and Stevens Johnson Syndrome (SJS) are severe adverse cutaneous drug reactions that predominantly involve the skin and mucous membranes. They are characterized by mucocutaneous tenderness and typically hemorrhagic erosions, erythema and more or less severe epidermal detachment presenting as blisters and areas of denuded skin. Drugs are assumed or identified as the main cause of SJS/TEN in most cases, but Mycoplasma pneumoniae and Herpes simplex virus infections are well documented causes alongside rare cases in which the etiology remains unknown. Several drugs are at “high” risk of inducing TEN/SJS including: Allopurinol, Trimethoprim-sulfamethoxazole and other sulfonamide-antibiotics, aminopenicillins, cephalosporins, quinolones, carbamazepine, phenytoin, phenobarbital and NSAID’s of the oxicam-type. Differential diagnosis includes linear IgA dermatosis and paraneoplastic pemphigus, pemphigus vulgaris and bullous pemphigoid, acute generalized exanthematous pustulosis (AGEP), disseminated fixed bullous drug eruption and staphyloccocal scalded skin syndrome (SSSS). Due to the high risk of mortality, management of patients with SJS/TEN requires rapid diagnosis, identification and interruption of the culprit drug, specialized supportive care ideally in an intensive care unit, and consideration of immunomodulating agents such as high-dose intravenous immunoglobulin therapy.


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How to Cite

Anne S ram, Kosanam S, N LP. . Int J of Pharmc Res [Internet]. 2014Dec.30 [cited 2020Nov.25];4(4):158-65. Available from:


Vol. 4 No. 4 (2014): Oct-Dec


Review Article

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

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