Protective role of food supplement Spirulina fusiformis in chemical induced hepatotoxicity: A Bromobenzene model in rats


Evan Prince Sabina, Sherry Joseph Martin, Mahima Vedi, Baskaran Udhaya Lavinya, Blossom Benny, Agnes Selina K, Anne Sahithi S T, Mahaboobkhan Rasool




The present study evaluated the efficacy of Spirulina fusiformis in protecting against chemical induced hepatotoxicity in rats using Bromobenzene as the candidate toxin. A single oral dose of bromobenzene (BB) (10mmol/kg b.w.) resulted in significant (p< 0.05) decrease in antioxidant levels (catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidese, total reduced glutathione and total protein), and significant (p< 0.05) increase in the levels of serum bilirubin, liver enzymes (alanine transaminase, aspartate transaminase and alkaline phosphatase) indicating the induction of hepatotoxicity. Spirulina fusiformis (400 mg/kg b.w) was orally administered for 8 days prior to the administration of BB and was seen to protect the above parameters from significant changes upon challenge with bromobenzene. This was also confirmed by the histological examination of liver tissues after sacrifice. The protective effect of Spirulina fusiformis was comparable to that of the standard hepatoprotective drug sylimarin.




Bromobenzene, Hepatotoxicity; Spirulina fusiformis; Antioxidants; Hepatoprotective


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