In vitro anti-diabetic activity of compounds from pithecellobium dulce fruit peel


Methodology

Authors


  • Praylin Singh


    Research Scholar,
    Womens Christian College, Nagercoil, Tamilnadu,

  • Prasanna Kumar Sugirtha


    Associate Professor,
    Department of Chemistry, Womens Christian College, Nagercoil ,Tamil Nadu

DOI:

https://doi.org/10.7439/ijpc.v5i4.1873

Keywords:


PPROM, conservative, Aggressive, neonatal sepsis, Respiratory distress syndrome

Abstract

Medicinal plants have been reported to play an important role in modulating glycemic responses and have preventive and therapeutic implications . The intestinal digestive enzymes plays a vital role in the carbohydrate digestion. The present investigation evaluated the possible action of isolated compounds through which pithecellobium dulce fruit peel exerts its hypoglycemic effect using suitable in vitro techniques. The isolated compounds were subjected to inhibitory effect of non-enzymatic glycosylation of hemoglobin assay and enzymatic alpha-amylase inhibition assay using specific standard invitro procedure. Non-enzymatic glycosylation of hemoglobin assay showed inhibitory activity of 73.7% and 53.9% at 1mg/ml. The IC 50 values of amylase inhibitory activity of compounds from pithecellobium dulce fruit peel was found to be 80.9% and 56.5% at 1mg/ml. Results in two different compounds revealed that the compound 1was found to be more potent than compound 2 at the concentrations 0.2mg/dl to 1.0mg/dl. The findings indicate Pithecellobium dulce fruit peel possess strong hypoglycemic effect and hence can be utilized as an adjunct in the management of diabetes mellitus.

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Author Biography

Praylin Singh, Research Scholar,
Womens Christian College, Nagercoil, Tamilnadu,

CHEMISTRY

Published

2015-04-30

How to Cite

1.
Singh P, Sugirtha PK. . Int J of Pharm Chem [Internet]. 2015Apr.30 [cited 2020May31];5(4):123-7. Available from: https://ssjournals.net/index.php/ijpc/article/view/1873

Issue

Vol. 5 No. 4 (2015): Apr

Section

Research Articles

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