Design, synthesis and evaluation of acute toxicity studies and anti-depressant activities of some new derivatives of 1, 3-benzoxazin- 4-one

Authors

Nachiket Dighe

Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS 413736
Pankaj S. Shinde

Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, -413736.
Ravindra B. Lawre

Department of Pharmaceutics,
Pravara Rural College of Pharmacy, Loni, MS, -413736.
Santosh B. Dighe

Department of Pharmacology,
Pravara Rural College of Pharmacy, Loni, MS, India-413736.
Deepak S Musmade

Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Loni, MS,

DOI:

https://doi.org/10.7439/ijpc.v5i5.1838

Abstract

This study was designed to synthesize, characterize and to evaluate the pharmacological activity of 1, 3-benzoxazin- 4-one derivatives. Totally thirteen compounds, were synthesized by conventional method. Purity of the synthesized compounds was ascertained by TLC and melting point determination by open capillary tube method and they were characterized by IR and NMR spectroscopic methods. Antidepressant activity of all the synthesized compounds was evaluated by despair swim test by using Sprague Dawley Rats. Standard drug Imipramine was used as the control. In the results of the spectral study, all the compounds showed characteristic peak in IR and NMR spectroscopy. In the despair swim test, all the synthesized derivatives showed antidepressant activity. Among them three Compounds (A₄, A₅ and A₇) showed significant antidepressant activity comparing with control drug imipramine. These results are useful for the further investigation in the future.

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Published

2015-05-30

How to Cite

Dighe N, Shinde PS, Lawre RB, Dighe SB, Musmade DS. . Int J of Pharm Chem [Internet]. 2015May30 [cited 2020May31];5(5):158-65. Available from: https://ssjournals.net/index.php/ijpc/article/view/1838

Issue

Vol. 5 No. 5 (2015): May

Section

Research Articles

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