Electrochemical Investigation of Dicyclomine Hydrochloride at Poly (Terbutaline Sulphate) Modified Carbon Paste Electrode


Methodology

Mamatha G. P, Deepak M. P.

 

Abstract

 

Dicyclomine Hydrochloride (DICY) has been studied on electropolymerisation of Terbutaline Sulphate (TBS) modified carbon paste electrode by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Voltammetric behavior of Dicyclomine Hydrochloride (DICY) on the poly (Terbutaline Sulphate) modified carbon paste electrode was investigated with electrochemical parameters of cyclic voltammetry. The variation of pH,Scan rate, Concentration of Dicyclomine Hydrochloride (DICY) has been studied. In optimal conditions, the oxidation peak current of DICY on the poly (Terbutaline Sulphate) modified carbon paste electrode was enhanced greatly indicating high sensitivity. The low detection limit (LOD) and low detection quantity (LOQ) of DICY has been found to be 0.12 µM and 0.408 µM with a correlation coefficient of 0.99461. The practical application of the modified electrode in the determination of DICY has good selectivity and high sensitivity.

 

Keywords

 

Terbutaline Sulphate, Dicyclomine Hydrochloride, Electropolymerization, Carbon Paste Electrode, Cyclic Voltammetry, Differential pulse voltammetry

 

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References

 

.Hedpara RJ, Vibhuti Chhatarala, Ashwin Agola. A Validated RP-HPLC method for the simultaneous estimation of paracetamol and dicyclomine Hydrochloride in pharamaceutical formulations. IJPSR 2013; 4(6): 2400-2405.

.Xu W, Lei R, Cao W,Guo C, Zhang X, Wang S.Voltammetric Method Using Mutli-Walled Carbon Nanotubes Modified Glassy Carbon Electrode for the Determination of Terbutaline Sulphate in Pork Sample. Journal of Analytical Sceinces Methods and Instrumentation 2013; 3:75-79.

. Roy PR, Okajima T, Ohsaka T. Simultaneous electroanalysis of dopamine and ascorbic acid using poly (N, N-dimethyl aniline)-modified electrodes. Bio electrochemistry 2003; 59(1-2): 11-9.

Xiao-Lin Wen, Yunhua Jia, Li Yang, Zhong-Li Liu. Electrocatalytic oxidation of L-tyrosine by a nitroxide. Talanta Elsevier 2001; 53: 1031–1036.

.Ekinci E, Erdogdu G, Karagozler AE. Preparation, Optimization, and Voltammetric Characteristics of Poly (o-phenylenediamine) Film as a Dopamine-Selective Po-lymeric Membrane. J. Appl. Polym. Sci 2001; 79: 327-332.

Pontie M, Gobin C, Pauporte T, Bedioui, F. and Devynck. Electrochemical nitric oxide microsensors: sensitivity and selectivity characterization. J. Anal. Chim. Acta 2000; 411: 175.

.Zhao H, Zhang YZ, Yuan ZB. Electrochemical Behavior of Norepinephrine at Poly (2, 4, 6-trimethylpyridine) Modified Glassy Carbon Electrode. Electroanal 2002; 14: 445-448.

. Zhao H, Zhang YZ, Yuan ZB. Poly (Isonicotinic acid) modified glassy carbon electrode for electrochemical detection of norepinephrine. Anal. Chim. Acta 2002; 454: 75-81.

. Caro CA, Bedioui F, Zagal JH. Electrocatalytic oxidation of nitrite on a vitreous carbon electrode modified with cobalt phthalocyanine. Electrochim. Acta 2002; 47:1489.

. Laviron E. J. Adsorption auto inhibition and autocatalysis in polarography and linear potential sweep voltammetry. Electroanal. Chem 1974; 52: 355-393.

. Deepak MP, Mamatha GP, Sherigara BS. Electrochemical Investigation of Uric acid at Poly (Isoniazid) film Modified Carbon Paste Electrode. IJPC, 2014; 4(4): 122-129.

 

DOI: http://dx.doi.org/10.7439/ijpc.v5i1.1605

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Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

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