Recurrent pregnancy loss – Chromosomal anomalies in couples



  • Ashalatha P R

    Associate Professor Ndepartment of Anatomy, Ngovernment Medical College Nkozhikode, Kerala, India Pin- 673008

  • Manju M

    Associate Professor, Department of Obstetrics and Gynaecology, Government Medical College, Kozhikode 673008

  • Shyja

    4Gene Technologist, Department of Anatomy, Government Medical College, Kozhikode-673008


Recurrent Pregnancy Loss (RPL), ReciprocalTranslocation, Robertsonian Translocation.


Background: Recurrent Pregnancy Loss (RPL) is an important reproductive health problem. The present study was carried out to find out the frequency and types of chromosomal anomalies in couples who consulted the Department of Obstetrics and Gynaecology, seeking treatment for RPL. They were examined and investigated at the Institute of Maternal and Child Health, Government Medical College, Kozhikode, which is a Tertiary care Centre of North Kerala.

Study Settings and Design: A retrospective study of karyotypes of 125 couples was done. The results of cytogenetic analysis over a period of 7 years were assessed.

Method: Peripheral blood lymphocytes were cultured according to standard protocol and karyotypes were analysed using Cytovision Software Version 7 and expertise of staff.

Results: Out of 125 couples, 114 (91.2%) couples had apparently normal karyotypes. Remaining 11 couples (8.8%) showed chromosomal anomalies.

Conclusion: This study shows the importance of karyotyping in couples with recurrent pregnancy loss. Early diagnosis and genetic counseling can be offered to affected couples.


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How to Cite

P R A, M M, Shyja. . Int Jour of Biomed Res [Internet]. 2021 Feb. 28 [cited 2022 Oct. 17];12(2):e5576. Available from:


Vol. 12 No. 2 (2021): Feb


Original Research Articles

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

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