Keywords:
Recurrent Pregnancy Loss (RPL), ReciprocalTranslocation, Robertsonian Translocation.
Abstract
Background: Recurrent Pregnancy Loss (RPL) is an important reproductive health problem. The present study was carried out to find out the frequency and types of chromosomal anomalies in couples who consulted the Department of Obstetrics and Gynaecology, seeking treatment for RPL. They were examined and investigated at the Institute of Maternal and Child Health, Government Medical College, Kozhikode, which is a Tertiary care Centre of North Kerala.
Study Settings and Design: A retrospective study of karyotypes of 125 couples was done. The results of cytogenetic analysis over a period of 7 years were assessed.
Method: Peripheral blood lymphocytes were cultured according to standard protocol and karyotypes were analysed using Cytovision Software Version 7 and expertise of staff.
Results: Out of 125 couples, 114 (91.2%) couples had apparently normal karyotypes. Remaining 11 couples (8.8%) showed chromosomal anomalies.
Conclusion: This study shows the importance of karyotyping in couples with recurrent pregnancy loss. Early diagnosis and genetic counseling can be offered to affected couples.
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