Hypercortisolaemia and dyslipidaemia in a selected diabetic population


Methodology

Authors


  • Adediji Isaac Oluwole


    Department of Medical Laboratory Science,
    Clinical Chemistry Unit,
    Babcock University,
    Ilishan Remo, Ogun State

  • Ayodele Ademola Adelakun


    Department of Chemical Pathology, LAUTECH Teaching Hospital, Ogbomoso.

  • Afolabi Joy Oluwaseyifunmi


    Department of Medical Laboratory Science,
    Clinical Chemistry Unit,
    Babcock University,
    Ilishan Remo, Ogun State

  • Akinleye Waheed A


    Department of Medical Laboratory Science,
    Clinical Chemistry Unit,
    Babcock University,
    Ilishan Remo, Ogun State

  • Taiwo Timilehin Darasimi


    Department of Medical Laboratory Science,
    Clinical Chemistry Unit,
    Babcock University,
    Ilishan Remo, Ogun State

DOI:



https://doi.org/10.7439/ijbr.v9i4.4538

Abstract

Background: Type II DM and obesity are metabolic disorders characterized by insulin resistance, dyslipidaemia, and metabolic stress. These features were assessed in patients using fasting plasma glucose, fasting lipid profile and serum cortisol as their markers. Materials and methods: Ninety participants were recruited and classified into 3 groups of thirty each Obese with type II DM, Non-obese with type II DM, non-obese and non-diabetics who served as controls. Anthropometric measures of weight and height were taken using standard procedures and body mass index was calculated thereafter. Blood samples were collected after an overnight fast for the in vitro assay of serum cortisol, plasma glucose, triglycerides, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol using enzyme linked immunosorbent assay and colorimetry as appropriate. Data obtained were analyzed statistically using ANOVA and post hoc test for comparison of variables between groups. Pearson correlation was performed to assess the relationship between variables and p 0.05 was considered significant. Results: Serum cortisol, plasma glucose, total cholesterol, triglycerides and LDL-cholesterol were elevated while HDL-cholesterol was reduced in both obese and non-obese subjects with type II diabetes mellitus when compared with controls. Cortisol had a significant positive association with plasma glucose, total cholesterol, triglycerides and LDL-cholesterol in obese subjects with type II diabetes mellitus while cortisol had a significant inverse relationship with HDL-cholesterol in both obese and non-obese subjects with type II diabetes mellitus. Conclusion: From this study, we conclude that elevated serum cortisol, a consequence of type II DM, accompanies dyslipidaemia in both obese and non-obese type II DM patients. It could therefore be inferred that ˜diabetic stress ™ is the underlying factor of elevated cortisol in this group.

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Published

2018-05-01

How to Cite

1.
Oluwole AI, Adelakun AA, Oluwaseyifunmi AJ, A AW, Darasimi TT. . Int Jour of Biomed Res [Internet]. 2018May1 [cited 2020May29];9(4):143-7. Available from: https://ssjournals.net/index.php/ijbr/article/view/4538

Issue

Vol. 9 No. 4 (2018): Apr

Section

Original Research Articles

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

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