Abstract
Objectives: To categorize the lesions of liver observed on FNAC into malignant or benign, to correlate the radiological observations with cytology findings and to perform histopathological correlation wherever possible.
Material and methods: A total of 150 cases underwent ultrasonography-guided FNAC, in whom lesion/pathology in the liver was suspected and hepatic mass was confirmed on radiological examination with normal prothrombin time. This study was performed on admitted and OPD patients of SRMS IMS, Bareilly from November 2014 to May 2016.
Results: Of the total 150 cases, 4 liver aspirates were inadequate for cytological evaluation and were excluded. Most cases (48 cases; 32.87%) were found in the 6th decade. Radiological findings revealed that out of 146 cases, 6(4.10%) were benign and 140(95.9%) were malignant, while cytological examination revealed 13(8.90%) as benign and 133 (90.09%) as malignant. Among malignant cases, 93.2% were metastatic, the commonest being metastatic adenocarcinoma. Correlation between radiodiagnosis and FNAC was evaluated, which revealed a significant change. Sensitivity and specificity of FNAC were 90.00% and 100% respectively. Accuracy of FNAC was observed to be 90.5% when compared with histopathology; however, the latter was available in very small number of cases.
Conclusion: Categorisation of liver lesions into malignant or benign can be done on FNAC with high accuracy. Guided FNAC is very useful in diagnosis of different hepatic lesions as the procedure is simple and safe. The results are obtained quickly without serious complications related to the procedure.
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References
Kuo FY, Chen WJ, Lu SN, Wang JH, Eng HL. Fine needle aspiration cytodiagnosis of liver tumors. Acta Cytol 2004; 48:142?8.
deBoer B. Liver and Spleen. In: Orell SR, Sterrett GF, editors. Fine needle aspiration cytology. 5th ed. New Delhi: Churchill Livingston; 2012.p.271-296.
Das DK, Tripathi RP, Kumar N, Chachra KL, Sodhani P, Parkash S et al. Role of guided FNAC in diagnosis and classification of liver malignancies. Trop Gastroenterol 1997; 18(3):101-106.
Bobhate S, Kumbhalkar DT, Nayak SP. Guided (US&CT) FNAC of abdominal masses and spinal lesions. J Cytol 2001; 18(3):137-14-25.
Wee A. FNA biopsy of the liver: Algorithmic approach and current issues in the diagnosis of hepatocellular carcinoma. Cyto Journal 2005; 2:7.
Swamy MCM, Arathi C, Kodandaswamy C. Value of USG?guided FNAC in the investigative sequence of hepatic lesions with an emphasis on hepatocellular carcinoma. J Cytol 2011; 28:178?84.
Chhieng DC. FNA biopsy of liver- an update. World Journal of Surgical Oncology 2004; 2:5.
Rasania A, Pandey CL, Joshi N. Evaluation of FNAC in diagnosis of hepatic lesion. J Cytol 2007; 24:51-54.
Nazir RT, Sharif MA, Iqbal M, Amin MS. Diagnostic accuracy of FNAC in hepatic tumors. J Coll Physicians Surg Pak 2010; 20:373-6.
Franca AV, Valeric HM, Trevisan M, Escanhoela C, Seva-Pereira T,
Zucoloto S, et al. FNA biopsy for improving the diagnostic accuracy of cut needle biopsy of focal liver lesions. Acta Cytol 2003; 47(3):332-36.
Nasit JG, Patel V, Parikh B, Shah M, Davara K. FNAC and biopsy in hepatic masses: A minimally invasive diagnostic approach. Clin Cancer Investig J 2013; 2:132-42.
Ali SR, Jayabackthan L, Rahim S, Sharel MB, Prasad K, Hegdekatte N. Role FNAC in the diagnosis of hepatic lesions. Muller J Med Sci Res, 2015; 6:125-8.
Bell DA, Carr CP, Szyfelbein WM. FNAC of focal liver lesions: Results obtained with examination of both cytologic and histologic preparations. Acta Cytol 1986; 30:397 402.
Talukder SI, Huq MH, Haque MA. USG guided FNAC for diagnosis of mass lesions of liver. Mymensingh Med J 2004; 13:25-9.
Guo Z, Kurtycz DF, Salem R, De Las Casas LE, Caya JG, Hoerl HD. Radiology guided percutaneous FNA biopsy of the liver: Retrospective study of 119 cases evaluating diagnostic effectiveness and clinical complications. Diagn Cytopathol 2002; 26(5):283 9.
Nggada HA, Ahidjo A, Ajagi NA. Correlation between ultrasound findings and ultrasound guided FNAC in the diagnosis of hepatic lesions: A Nigerian tertiary hospital experience. Int J Gastroenterol 2006; 5(2):1-7.
Goel S, Hemrajani D, Sharma M. USG guided FNAC in diagnosis of space occupying lesions of liver. Journal of Evolution of Med and Dent Sci 2014; 3(27):7480-7486.
Orell SR, Sterrett GF, Walters MN, Whitaker D. Retroperitoneum, liver and spleen. In: Manual and atlas of FNAC. 2nd ed. Hong Kong: Churchill Livingstone 1992:217-266.
Tao LC, Donat EE, Ho CS, McLoughlin MJ. Percutaneous FNA biopsy of the liver: Cytodiagnosis of hepatic cancer. Acta Cytol 1979; 23:28791.
Barbhuiya M, Bhunia S, Kakkar M, Shrivastava B, Tiwari PK, Gupta S. FNAC of lesions of liver and gallbladder: An analysis of 400 consecutive aspirations. J Cytol 2014; 31:20-4.
Kapadiya DN, Varadharajaperumal R, Santwani PM. USG guided FNAC of liver: four year study. IJAR 2015; 3(12):523-527.
Singh S, Sen R, Kumar S, et al. Profile of Liver FNA in Tertiary Care Hospital. Euroasian J Hepato Gastroenterol 2013; 3(1):31-35.
Cochand-Priollet B, Chagnon S, Ferrand J, Blery M, Hoang C, Galian A. Comparison of cytologic examination of smears and histologic examination of tissue cores obtained by FNA biopsy of the liver. Acta Cytol 1987; 31:476-80.
Tsai YY, Lu SN, Changchien CS, Wang JH, Lee CM, Eng HL, et al. Combined cytologic and histologic diagnosis of liver tumors via one-shot aspiration. Hepato-Gastroenterol 2002; 49:644-7.
Jenssen C, Dietrich C. Endoscopic USG-guided FNA biopsy and trucut biopsy in gastroenterology- an overview. Best Pract Res Clin Gastroenterol 2009; 23:743-59.
Maheshwari A, Kantsevoy S, Jagannath S, Thuluvath PJ. Endoscopic ultrasound and FNA for the diagnosis of hepatocellular carcinoma. Clin Liver Dis 2010; 14(2):325-32.
DOI: https://doi.org/10.7439/ijbr.v8i2.3880
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