Serum cholinesterase as diagnostic marker of liver disease


Ruchi Shantilal Gokani, Pranay Jadav, Nadeem Shaikh, Rita Shah, Mitul Chhatriwala, Bhavita Patel




Background:Liver disease is leading cause of morbidity and mortality worldwide. Cholinesteraseis a family of enzymes thatcatalysethehydrolysisof the neurotransmitteracetylcholineintocholineandacetic acid. It is an enzyme synthesized by hepatocytes and its serum levels reflect the synthetic function of liver.

Objectives:To estimate serum cholinesterase in liver disease patients and to compare serum cholinesterase level with other liver function tests like SGOT, SGPT, ALP and Bilirubin levels.

Methodology:The present cross sectional study was conducted at the Biochemistry department of tertiary care institute.Thirty patients with liver disease were included in the group A and 30 healthy patients not having liver disease were enrolled in group B as control .Serum cholinesterase and Liver Function Tests were estimated in all participants.

Results:The level of cholinesterase were significantly lower in liver disease patients.Serum cholinesterase was 3424.77 2149.30 in group A vs.7320.77 1577.26 in group B (P<0.05). It is 90% sensitive and 100% specific.

Conclusion:From the present study it is concluded that serum cholinesterase can serve as better diagnostic marker of liver disease.




Serum cholinesterase, Liver Function Test, Sensitivity


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Copyright (c) 2014 International Journal of Biomedical and Advance Research

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