Effect of Vitamin B12 on Liver function of albino rats infected with Trypanosoma brucei



  • Adebayo Olugbenga Adegoke

    Department of Medical Laboratory Science, Madonna University

  • Nnatuanya I. N.

    Department of Medical Laboratory Science, Madonna University, Elele

  • Odeghe Othuke Bensandy

    Department of Biochemistry, Faculty of Science Madonna Unversity

  • Edoga Cyril

    Department of Physiology, Faculty of Science Madonna University




Trypanosnma brucei brucei, Vitamin B12, Liver


This study was carried out to determine the effect of vitamin B12 on the liver function of male wistar albino rats infected with Trypanosnmabrucei brucei, 24 male Wistar albino rats were divided into 6 groups namely; Control , Trypanosome infected, Diamenazene treated, 40mcg vitaminB12, 60mcg vitaminB12, 80mcg vitaminB12,,the liver indicators such as alkaline phosphatase(ALP),aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin and direct bilirubin were determined in the rats using kinetic method for ALP,AST and ALT and diazo method for total and direct bilirubin.the data was subjected to statistical analysis using SPSS vision 20.there was a significant increase(p<0.05) in the serum activities of alkaline phosphatase(ALP),aspartate aminotransferase(AST),alanine aminotransferase(ALT) and concentration of total bilirubin and direct bilirubinwith a mean value of (trypanosome infected 137.45


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How to Cite

Adegoke, A. O., N., N. I., Bensandy, O. O., & Cyril, E. (2020). . International Journal of Biomedical and Advance Research, 11(1), e5165. https://doi.org/10.7439/ijbar.v11i1.5165


Vol. 11 No. 1 (2020): Jan


Original Research Articles

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

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