Hypothyroidism and possible association with Metabolic Syndrome

Background: Thyroid dysfunctions are the most common forms of endocrine disorder in our country, Thyroid hormones perform a wide array of metabolic functions including regulation of lipids, carbohydrates, protein and electrolytes and mineral metabolism, Thyroid hormones are major regulatory hormones that controls the rate of metabolic function and alteration in the levels of thyroid hormones may be associated with metabolic syndrome

Aim: The study was performed to investigate the association between Altered thyroid state i.e hypothyroidism and metabolic syndrome.

Materials and Methods: The study was done on patients with symptoms of hypothyroidism or follow up cases of hypothyroidism having metabolic syndrome. T3, T4 and TSH and were analyzed by enzyme linked fluorescent assay (ELFA) technique using Vidas auto analyzer from Biomeriuex, France. Fasting blood sugar and lipid profile were estimated by Erba Chem 7 semi-auto analyzer. The data was analyzed using SPSS-17 software package.

Results: The percentage of metabolic syndrome and hypothyroidism in each age group were determined and we have found that the percentage of metabolic syndrome is increasing with age and is highest 60 % in the age group of 61-75 years, both T3, T4 are comparably decreased but TSH is on the higher side in metabolic syndrome as compared to non-metabolic syndrome

Conclusion: Patients having Thyroid dysfunction should regularly be checked for parameters of metabolic syndrome: Early detection of thyroid dysfunction and treatment can prevent the complications of metabolic syndrome.

T3, T4, TSH, Metabolic syndrome & Thyroid disorders

Kochupillai N. Clinical Endocrinology in India. Curr. Sci. 2000; 79(10): 1061-1067.

Vanderpump MP, Turnbridge WM, Epidemiology and prevention of clinical and subclinical hypothyroidism. Thyroid. 2002; 12(10): 839-847.

Ahmad N, Taliyan S, Bandyopadhyay D, Baruah H, Gupta A. Prevalence of Thyroid Hormone Abnormalities among patients in Subharti university- A Hospital based study. Journal of Advance Researches in Biological Sciences. 2013; 5(4): 357-361.

Dilutpal Sharma, Amit Vasant Deshpande, Naved Ahmad, Akash Gupta. Thyroid Disorders in Greater Noida: A hospital based study. Int Jour Biomed Res. 2014; 05 (04):274-276.

Pearce EN. Hypothyroidism and dyslipedemia: modern concepts and approaches. Curr Cardiol Rep. 2004;6(6):451-456

Naiyar Azam, Ashish Shukla, Naved Ahmad, Akash Gupta. Altered thyroid profile in metabolic syndrome. Int Jour Biomed Res. 2014; 05 (11):692-694

Dillmann WH. Mechanism of action of thyroid hormones. Med Clin North Am. 1985; 69 (5):849-61.

Waring AC, Rodondi N, Harrison S, Kanaya AM, Simonsick EM, Miljkovic I, et al. Thyroid Function and Prevalent and incident Metabolic Syndrome in older Adults: The Health, Ageing and Body Composition Study. Clin Endocrinol (Oxf). 2012; 76(6): 911-8.

Heima NE, Eekhoff EM, Oosterwerff MM, Lips PT, van Schoor NM, Simsek S. Thyroid function and the metabolic syndrome in older persons: a population-based study. Eur j Endocrinol. 2012; 168(1): 59-65.

Jha S, Ahmad N. Prevalence of Thyroid Dysfunction in the Patients ‘Visiting Tertiary Health Care Hospital, Faridabad; Haryana. International Journal of Scientific Research. 2013; 2(10):1-2.

Bastemir M, Akin F, Alkis E, Kaptanoglu B. Obesity is associated with increased serum TSH level, independent of thyroid function. Swiss Med Wkly. 2007; 137(29-30): 431-434.

Waterhouse DF, McLaughlin AM, Walsh CD, Sheehan F, O’shea D. An examination of the relationship between normal range thyrotropin and cardiovascular risk parameters: a study in healthy women. Thyroid. 2007; 17(3): 243-248.

Fahimeh Ramezani Tehrani, Maryam Tohidi, Marzieh Rostami Dovom, Fereidoun Azizi. A Population Based Study on the Association of Thyroid Status with Components of the Metabolic Syndrome. J Diabetes Metab. 2011; 2(8): 1-6.

Park SB, Choi HC, Joo NS. The relation of thyroid function to components of the metabolic syndrome in Korean Men and Women. J Korean Med Sci. 2011; 26(4):540-45.

Pirjo IP, Johan GE, Jaana L, Helena H. Prevalence of the metabolic syndrome and its Components findings from a Finnish general population sample and the Diabetes Preventions Study Cohort. Diabetes Care. 2004; 27(9): 2135-40.

Park SB, Choi HC, Joo NS. The relation of thyroid function to components of the metabolic syndrome in korean men and women. J Korean Med Sci. 2011; 26(4): 540-5.

Ghanshyam Palamaner Subash Shantha. Anita A Kumar, Vijay Jeyachandran, Deepan Rajamanickam,K Rajkumar, Shihas Salim, et al. Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a crosssectional study from South India. Thyroid Research. 2009; 2: 2.

Gyawali P, Takanche JS, Shrestha RK, Bhattarai P, Khanal K, Risal P, et al. Pattern of thyroid dysfunction in patients with metabolic syndrome and its relationship with components of metabolic syndrome. Diabetes Metab J. 2015; 39(1):66-73.