Alterations in haematological parameters among workers of fuel stations in White Nile State, Sudan



  • Abozer Elderdery

    Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Aljouf University,

  • Ahmed M Elnour

    Faculty of Medicine and Health Sciences, University of El Imam El Mahdi

  • Nada Y Ali

    Faculty of Medicine and Health Sciences, University of El Imam El Mahdi

  • Abeer A Elsaken

    Faculty of Medicine and Health Sciences, University of El Imam El Mahdi

  • Remah E AbdElgabar

    Faculty of Medicine and Health Sciences, University of El Imam El Mahdi

  • Romisa A Elbashier

    Faculty of Medicine and Health Sciences, University of El Imam El Mahdi

  • Nawal EOmer

    Khartoum Medical University



Benzene exposure is one of the main health concerns for occupations with risk of exposure to volatile solvents such as petrol pump workers. Human exposure to benzene is associated with multiple adverse health effects including pancytopenia, hence aplastic anaemia and an increased risk of developing cancer (acute myeloblastic leukemia). Morphological effect on RBCs (microcytosis) also occurs. This cross sectional descriptive study involved workers at fuel stations in Kosti and Rabak cities, White Nile State, during December 2014-March 2015 and aimed to determine any alterations in haematological parameters among these employees. Workers at fifty fuel stations were recruited to participate, individually giving written informed consent. Venous blood (2.5 ml) was taken into EDTA containers and a full blood count (FBC) was done for each participant, using a fully automated haematology analyzer (Sysmex). The results from the fuel stations workers include the following high prevalence of abnormalities: Fifty percent had low haemoglobin levels, 60 percent low RBS counts (although 30% were higher than normal), haematocrit readings showed 24% with reduced values and for MCV 92% were reduced. Half of the participants showed microcytic cytology. The current study concluded that there are abnormalities in haematological parameters among fuel stations workers, particularly in Hb and RBC indices, as well as lymphocytosis and neutropenia. Workers at fuel stations should be protected from exposure to benzene by training with the equipment to minimising leakge and spillage and by wearing protective devices, such as masks and goggles. Further studies are necessary to determine the possible effects of benzene on haematological parameters among long-duration workers in fuel stations.


Download data is not yet available.


Metrics Loading …


Smith MT. Advances in understanding benzene health effects and susceptibility. Annu Rev Public Health. 2010;31:133-48 2 p following 48.

Patel AS, Talbott EO, Zborowski JV, Rycheck JA, Dell D, Xu X, et al. Risk of cancer as a result of community exposure to gasoline vapors. Arch Environ Health. 2004 Oct;59(10):497-503.

ATSDR. Toxicological Profile for Benzene. In US DHHS. PB/98/101157/AS: Agency for Toxic Substances and Disease Registry2007.

Marchetti F, Eskenazi B, Weldon RH, Li G, Zhang L, Rappaport SM, et al. Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men. Environ Health Perspect. 2012 Feb;120(2):229-34.

Mandiracioglu A, Akgur S, Kocabiyik N, Sener U. Evaluation of neuropsychological symptoms and exposure to benzene, toluene and xylene among two different furniture worker groups in Izmir. Toxicol Ind Health. 2011 Oct;27(9):802-9.

Kim S, Vermeulen R, Waidyanatha S, Johnson BA, Lan Q, Smith MT, et al. Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2246-52.

Renaud HJ, Rutter A, Winn LM. Assessment of xenobiotic biotransformation including reactive oxygen species generation in the embryo using benzene as an example. Methods Mol Biol. 2012;889:253-63.

Li XZ, Hu XJ, Xia ZP, Xuan ZQ, Yang J, Wang J. [Detection of DNA damage of workers occupationally exposed to lead with flow cytometer assay]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 May;27(5):266-9.

Wang L, He X, Bi Y, Ma Q. Stem cell and benzene-induced malignancy and hematotoxicity. Chem Res Toxicol. 2012 Jul 16;25(7):1303-15.

Ermolina EV, Stadnikov AA, Smoliagin AI. [Morphological features of the organs of the immune system in conditions of exposure to chromium and benzene]. Gig Sanit. 2012 May-Jun(3):69-71.

Khalade A JM, Pukkala E, Jaakkola JJ. Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis. Environ Health. 2010;31(9).

Kang SK, Lee MY, Kim TK, Lee JO, Ahn YS. Occupational exposure to benzene in South Korea. Chem Biol Interact. 2005 May 30;153-154:65-74.

D’Andrea MA, Reddy GK. Hematological and hepatic alterations in nonsmoking residents exposed to benzene following a flaring incident at the British petroleum plant in Texas City. Environ Health. 2015;14:115.

SM M. Hematological, Biochemical and Blood Lead Level Profile among Gasoline Exposed Station Workers in Sulaimaniya City. ARO The Scientific Journal of Koya University. 2014;36(10):6-12.

Uzma N, Salar BM, Kumar BS, Aziz N, David MA, Reddy VD. Impact of organic solvents and environmental pollutants on the physiological function in petrol filling workers. Int J Environ Res Public Health. 2008 Sep;5(3):139-46.

Hamad A. Some Biochemical and Hematological Alterations Associated with Lead Exposure in Gasoline Station Workers in Gaza Strip, M.Sc.thesis. the Islamic University-Gaza. Faculty of Science.; 2008. p. 37-58.

Pesatori AC, Garte S, Popov T, Georgieva T, Panev T, Bonzini M, et al. Early effects of low benzene exposure on blood cell counts in Bulgarian petrochemical workers. Med Lav. 2009 Mar-Apr;100(2):83-90.




How to Cite

Elderdery, A., Elnour, A. M., Ali, N. Y., Elsaken, A. A., AbdElgabar, R. E., Elbashier, R. A., & EOmer, N. (2015). . International Journal of Biomedical and Advance Research, 6(11), 780–784.


Vol. 6 No. 11 (2015): Nov


Original Research Articles

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

Leave a Comment