CLINICAL STUDY OF RADIO ACTIVE IODINE UPTAKE IN DIFFERENT GOITRE CASES IN CO-RELLATION WITH NORMAL INDIVIDUALS

ABSTRACT to measure the radioactive iodine uptake in different variants of goiter                                                                                              MATERIALS & METHODS subjects were divided into two group’s one group with normal levels of T _3,T₄ & TSH and no goiter which is control group and the other one is examination group which is divided in to three sub groups eu-thyroid goiter, hypo-thyroid goiter and hyper-thyroid goitre cases. Each group ishaving 10 subjects. All the subjects are females aged 35 yrs±5 and no one is receiving any drugs since 6 weeks just before the beginning of the study.Radio active iodine uptake is measured by using kits. Radio active iodine uptake is measured at 2,24 and 48 hrs.

RESULTS AND OBSERVATIONS At 2 hrs:in hypo-thyroid cases RAIU is elevated,in hyper-thyroid subjects RAIU uptake is increased and in eu-thyroid subjects the uptake is decreased. At 24 hrs:in hypo-thyroid cases RAIU is decreased, in hyper-thyroid subjects RAIU uptake is increased and in eu-thyroid subjects the uptake is decreased.At 48 hrs:RAIU uptake is reduced in hypo-thyroid individuals, in hyper-thyroid subjects the uptake is increased and in eu-thyroid subjects the uptake is decreased

CONCLUSION The Radio active iodine uptake is reduced at 2 hrs, 24 hrs and 48 hrs in eu-thyroid subjects.Radio active iodine uptake is increased at 2 hrs and decreased at 24 hrs and 48 hrs in hypo-thyroid subjects Radio active iodine uptake is reduced at 2 hrs, 24 hrs and 48 hrs in hyper-thyroid subjects.