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Breast carcinoma
Abstract
Introduction: Breast carcinoma is the most common cancer among women. Prognosis and management of breast cancer are influenced by classic variables such as grade, stage, hormone receptor status of estrogen (ER), progesterone (PR) and Her2/neu over expression. Though hormone receptor analysis is a prerequisite in this era, for management and prognosis, still histopathological grading can be taken up as an important variable for predicting prognosis.An attempt has been made in this study to correlate histopathological grade with hormone receptor status in breast carcinomas in our institution. Objectives: To correlate the Histopathological grade with ER, PR and Her2/neu receptor status of breast carcinoma
Materials and Methods: A prospective study conducted from June 2011 to June 2014 in the department of Pathology, ESIC Medical College and PGIMSR, ESIC Model Hospital, Rajajinagar, Bangalore. Hundred Modified radical mastectomy specimens were subjected for routine histological examination and Immunohistochemical analysis. Clinical details were archived from the files. Statistical analysis was done and p value of 0.05 were taken as significant using chi-square test.
Results: The age of the patients ranged from 24 to 75 years. Majority of tumours were predominantly of histopathological grade two. By Immunohistochemistry 52% were ER+/PR+, 25% were Her2/neu positive and 20% of triple negatives. A significant association was seen between histologic grade and hormone receptor status.
Conclusion: Histologic gradingtogether with receptor status offers an excellent method of correlation of survival rate and response to hormonal therapy which lightens up a prospect of various treatment modalities.
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