A study of the prescribing pattern of antimicrobial agents in a Tertiary care teaching hospital of Andaman & Nicobar Island

Background and Objectives: Antimicrobial agents are one of the greatest discoveries in recent times, and are also being used somewhat irrationally for various diseased states. It has lead to the development of resistance; increase in the number of Adverse Drug Reactions (ADRs), also the health of the patient is being compromised especially when antibiotics are prescribed irrationally. This study was done with the aim of assessing the antibiotics usage in a tertiary care teaching hospital in Port Blair, Andaman & Nicobar Island.

Materials & method: Auditing of the prescription from various clinical departments was done over a period of 8 months, from August 2016 to March 2017was done to assess the use of antimicrobials. Total 3852 prescriptions were analyzed for average number of drugs prescribed, antimicrobials prescribed by generic name or brand name, percentage of antibiotics among the prescribed drugs. And the data was analyzed in percentage and proportions.

Observations: A total of 3852 prescriptions from the Outdoor Patient Department of the hospital were analyzed in this study and out of those patients, male patients were 2000(51.9%) and female patients were 1852(48.1%) with male: female ratio of 1.07:1. The most common age group which was prescribed antibiotics was 21-40 years, followed by 1-20 years age group. Out of the 3852 prescriptions, 2360(61%) patients were prescribed 2 drugs in the prescription, followed by 1120(29%) patients with 3 drugs in a prescription. Generic name of the drugs was used in 2910(75.5%) prescriptions and brand name in 942(24.5%) prescriptions. 1698(44%) prescriptions containing antibiotics were prescribed empirically on the basis of provisional diagnosis. Amoxicillin- Clavulanic acid was prescribed in 1437(37%) patients, followed by Azithromycin in 862(22%) patients.

Conclusion: Stress must be laid towards the rational use of Antibiotics before its too late as already there is worldwide emergence of antibacterial resistance, moreover the irrational use of antibiotics is increasing side effects and total cost of treatment as well.

Audit, Prescription, Antibiotics, Rational use.

Tripathi KD. Antimicrobial drugs, Essentials of Medical Pharmacology.7th Edition, 12. New Delhi Jaypee Brothers Medical Publishers, 2013; 688-703.

Woldu MA, Suleman S, Workneh N, Berhane H. Retrospective study of the pattern of antibiotic use in Hawassa University Referral Hospital Pediatric Ward, Southern Ethiopia; J App Pharm Sci; 2013;3(02):93-8.

World Health Organization Financing of Health in India Available from: http://www.ino.searo.who.int/Linkfiles/ Other_Content_WHD11-Seminar _Presentation-WRpdf.

Amane H, Kop P. Prescription analysis to evaluate rational use of antimicrobials. Int J Phar. ma and Biosci 2011; 2(2); 314-319.

Ernest J.S. Resistance to antimicrobials in humans and animals. BMJ; 2005; 331:1219-20.

Goossens H. Antibiotic consumption and link to resistance. Clin Microbiol Infect. 2009 Apr; 15 Suppl 3:12-15.

MacDougall C, Polk RE. Antimicrobial stewardship programs in health care systems. Clin Microbiol Rev; 2005 Oct; 18(4): 638-56.

Khan FA, Singh VK, Sharma S, Singh P. Prospective Study on the Antimicrobial Usage in the Medicine Department of a Tertiary Care Teaching Hospital. Journal of Clinical and Diagnostic Research; 2013; 7(7): 1343-46.

Das BP, Sethi A, Rauniar GP, Sharma SK. Antimicrobial utilization pattern in outpatient services of ENT department of tertiary care hospital of Eastern Nepal. Kathmandu Univ Med J. (KUMJ) 2005; 3:370-75.

Sharma R, Khajuria B. Prescribing practices of doctors in rural and urban India. J Clin Diag Res 2009; 3; 1480?82.

Babalola CP, Awoleye SA, Akinyemi JO, Kotila O. Evaluation of prescription pattern in Osun State (Southwest) Nigeria. J Public Health Epidem 2011; 3:94?8.

Saurabh MK, Jaykaran, Yadav AK, Jyoti N. Study of prescribing pattern and assessment of rational use of drugs in tertiary hospital, Rajasthan. J Pharm Res 2010; 3(3):474?7.

Patel V, Vaidya R, Naik D, Borker P. Irrational drug use in India: A prescription survey from Goa. J Postgrad Med. 2005; 51:9?12.

Hanssens Y, Ismaeili BB. Antibiotic prescription pattern in a medical intensive care unit in Qatar. Saudi Med J 2005; 26:1269-76.