Complex of a new racemic thiourea substrate: Spectrophotometric study and separation of atropisomers

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Methodology

Authors


  • Yahya Salma


    Laboratory of Applied Chemistry (LAC),
    Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli

  • Hassan Zakaria


    Laboratory of Applied Chemistry (LAC),
    Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli

  • Inas EL Hassan


    Laboratory of Applied Chemistry (LAC),
    Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli

  • Mohammad Bouchekara


    Department of Chemistry,
    Faculty of Sciences and Technologies, University Mustapha Stanbouli of Mascara (29000),

  • Hanna El-Nakat


    Department of Chemistry,
    Faculty of Science, University of Balamand, P.O. Box 100, Tripoli,

  • Fawaz El Omar


    Laboratory of Applied Chemistry (LAC),
    Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli

  • Ahmad Khodr Allouch


    Laboratory of Applied Chemistry (LAC),
    Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli,

DOI:

https://doi.org/10.7439/ijpc.v8i1.4681

Abstract

The activity of a chiral molecule can vary from one atropisomer to the other. In this study, the separation of racemic-N-(2-methylphenyl), N ™-(2-chlorophenyl) thiourea (H2L2), a hydrophobic heavy metal trap, has been studied using reversed-phase high-performance liquid chromatography (RP-HPLC) with hydroxypropyl-beta-cyclodextrin (HP-β-CD) as a complexing additive to the racemic mixture and hexane-isopropanol as a mobile phase. The stoichiometry and the overall association constant of the complex have been determined using the continuous variation (Job’s plot) method and the Scott’s method respectively.

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Author Biography

Ahmad Khodr Allouch, Laboratory of Applied Chemistry (LAC),
Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli,

Department of chemistry,

Professor

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Published

2018-04-19

How to Cite

1.
Salma Y, Zakaria H, EL Hassan I, Bouchekara M, El-Nakat H, El Omar F, Allouch AK. . Int J of Pharm Chem [Internet]. 2018Apr.19 [cited 2020Jul.5];8(1):01-6. Available from: https://ssjournals.net/index.php/ijpc/article/view/4681

Issue

Vol. 8 No. 1 (2018): Jan

Section

Research Articles

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